中文摘要：

目的研究母鼠器官形成期经口暴露较低浓度的有机磷农药-敌百虫,对母鼠生殖功能、内分泌功能及胚胎发育的影响。方法孕鼠随机分为对照组和3个实验组,在胎儿器官形成期即妊娠第6～15d经口灌胃染毒敌百虫,剂量分别为0,12.5,25和50 mg/kg。在妊娠第17d经眼球取血后处死孕鼠,研究在本实验剂量下,敌百虫对孕鼠生殖功能、内分泌功能以及胚胎发育的影响。结果（1）母鼠器官形成期经口暴露敌百虫,可导致各实验组胎鼠外观畸形发生率显著增高（P〈0.01）。（2）各剂量敌百虫暴露对孕鼠的生育力及妊娠结局无明显影响,表现在孕鼠的体重、卵巢脏器系数、胎盘脏器系数、黄体数、着床率、活胎数、死胎数、吸收胎数等与对照组比较差异无统计学意义（P〉0.05）;（3）除50mg/kg剂量敌百虫的暴露可引起母鼠血清雌二醇浓度下降外,其他各剂量组母鼠血清和卵巢的雌二醇浓度均未见明显影响。结论在本实验剂量下,器官形成期雌鼠经口暴露敌百虫对子代胚胎的生长发育有影响,表现为胎鼠的畸形发生率增加,但对母鼠的生殖功能、内分泌功能未见明显影响。

英文摘要：

Objective Trichlorfon, an organophosphate pesticide, was evaluated for its potential effects to produce teratogenicity, reproductive and endocrine toxicity following maternal exposure during organogenesis in mice. Methods The pregnant mice were randomly divided into 4 groups, 3 for exposed and 1 for control, and were administrated doses of 0, 12.5, 25 and 50mg/kg trichlorfon respectively by gavage on gestation day 6 through day 15. All the mice were sacrificed on gestation day 17, in the mean time, the reproductive, endocrine and developmental toxicity were evaluated. Results （ 1 ） The rate of malformed fetuses were obviously increased in each exposed group compared with that of control group, （ P 〈 0.01 ）. （2） Exposure to trichlorfon during organogenesis, showed no obvious effects on maternal reproduction and gestation, such as maternal weights gain, ovary viscera coefficient,placenta viscera coefficient , number of corpora lutea, number of implantation sites, number of live fetuses, number of dead fetuses and number of resorbed fetuses （P〉0.05）. （3） There was no obviously affection in the concentration of serum and ovary estradiol in all groups except the concentration of serum estradiol was significantly reduced in 50mg/kg group（ P 〈 0.05） . Conclusion Under the doses of this study, it is suggested that trichlorfon causes teratogenicity without significant maternal reproductive and endocrine toxicities after maternal exposure during organogenesis.