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基于Meta分析的宣肺法治疗支气管哮喘临床研究系统评价
  • ISSN号:1672-0482
  • 期刊名称:《南京中医药大学学报》
  • 时间:0
  • 分类:R242[医药卫生—中医临床基础;医药卫生—中医学]
  • 作者机构:南京中医药大学基础医学院,江苏南京210023
  • 相关基金:国家自然科学基金(81072748,81473580).
中文摘要:

目的对宣肺法治疗支气管哮喘急性发作期的临床研究进行系统评价。方法检索中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据在线知识服务平台、中国生物医学文献数据库(CBM)、Cochrane图书馆、Medline、Embase,纳入有关宣肺法治疗支气管哮喘急性发作期的随机对照试验(RCT)和半随机对照试验(CCT),以Jadad改良质量评价标准对纳入的研究进行质量评价,采用Stata10.0进行Meta分析。结果符合质量评价的有7个RCT、7个CCT,共1118名受试者。Meta分析结果显示,RCT中药联合西医常规疗法优于单纯西医疗法(OR=5.16,95%CI[2.67,9.97],P〈0.05);CCT中药组与对照组相比疗效较好(RR=1.15,95%CI[1.09,1.23],P〈0.05)。发表偏倚方面,RCT组不存在发表偏倚,CCT组存在发表偏倚。结论宣肺法治疗支气管哮喘与西药治疗相比具有一定的优势,临床研究的质量有待进一步提高。

英文摘要:

OBJECTIVE To sy stematically evaluate the efficiency of dispersing lung method in treating acute attack of bronchial asthma.METHODS Relevant data were retrieved from Chinese Journal Full Text Database(CNKI),Chinese Science and Technology Journals Full Text Database(VIP),Wan Fang data online knowledge service platform,Chinese Biomedical Literature Database(CBM),Cochrane Library,Medline and Embase.Randomized controlled trials(RCTs)and semi-randomized controlled trials(CCTs)concerning acute attack of bronchial asthma treated with dispersing lung method were included,methodological quality were assessed based on improved Jadad evaluation criteria and Stata10.0software was used for statistical analysis.RESULTS A total of 1 118 subj ects from 7RCTs and 7CCTs met the inclusion criteria.The Meta analysis showed that traditional Chinese medicine combined with conventional western medicine therapy in RCTs were superior to simple western treatment(OR=5.16,95% CI[2.67,9.97],P〈0.05).Compared to control group,curative effects of traditional Chinese medicine group in CCTs were better(RR=1.15,95% CI[1.09,1.23],P〈0.05).Publication bias was found in CCTs,not in RCTs.CONCLUSION Disp ersing lung method has certain advantages over western medicine therapy in the treatment of bronchial asthma,and the quality of clinical research deserves further research.

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期刊信息
  • 《南京中医药大学学报》
  • 北大核心期刊(2011版)
  • 主管单位:江苏省教育厅
  • 主办单位:南京中医药大学
  • 主编:范欣生
  • 地址:南京市仙林大学城仙林大道138号
  • 邮编:210023
  • 邮箱:
  • 电话:025-85711934 85811935
  • 国际标准刊号:ISSN:1672-0482
  • 国内统一刊号:ISSN:32-1247/R
  • 邮发代号:28-232
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:18464