中文摘要：

阿尔茨海默病（Alzheimer＇s disease,AD）与铁代谢异常密切相关。目前研究发现人脑内有生物磁铁矿的存在。磁铁矿是一种含有两种价态铁的铁氧复合物,呈反铁磁性耦合,在AD病人脑中其含量和结构均出现异常,表明磁铁矿在AD的发病中可能发挥重要作用,氧化应激可能是磁铁矿发挥作用的一个重要途径。深入研究磁铁矿的形成机制以及调控因素,可以为解析AD的发病机制,以及电磁场生物学效应提供新的科学依据。

英文摘要：

Alzheimer＇s disease（AD） is closely correlated with abnormal iron metabolism.It has been shown that biological magnetite was identified in the human brain.Magnetite is a iron oxide compound with alternating lattices of antiferrimagnetically coupled Fe2＋ and Fe3＋.In the AD,the content and structure of magnetite are all abnormal,indicating that magnetite may play an important role in the pathogenesis of AD,and of which oxidative stress is probably a route.Study on the mechanism of magnetite formation and regulatory factors can provide a new scientific evidence for AD pathogenesis and biological effect estimation of electromagnetic field.