中文摘要：

目的：综述人脂肪组织来源干细胞的生物学特性及其在缺血性心脏病中的应用,分析不足,并在此基础上提出未来研究要解决的问题,以期为临床治疗提供依据。 资料来源：应用计算机检索Blackwell、Elsevier、Pubmed数据库1980/2007期间脂肪源性干细胞与缺血性心脏病方面的文献,检索词为“bone mesenchymal stem cells,adipose derived stemcells,cardiomyocytes,ischemic heart disease”等。应用计算机检索中国期刊全文数据库1980/2007期间相关文献,检索词为“骨髓间充质干细胞,脂肪组织来源的干细胞,心肌细胞,缺血性心脏病”等。并手工查阅相关书籍。 资料选择：对资料进行初步选择：①脂肪组织来源干细胞的生物学特性。②脂肪组织来源干细胞治疗缺血性心脏病。排除重复文献。 资料提炼：共搜集到相关文章57篇,删除内容重复及与本文主题关系较远的文章,剩余41篇作为综述参考。 资料综合：脂肪组织来源干细胞与同样起源于中胚层的骨髓基质细胞不仅具有非常相似的生物学特性,而且在细胞表面标志谱的表达方面也非常相近。并且脂肪组织来源广泛,取材方便,可获得的基质细胞数量大,易于培养扩增。有研究发现,脂肪组织来源干细胞体外培养不需要任何诱导便能分化成具有自律性的心肌细胞,使得脂肪组织来源干细胞治疗缺血性心脏病成为可能。 结论：脂肪组织来源干细胞在取材和增殖方面较骨髓间充质干细胞有优势;脂肪组织来源干细胞能较好的诱导为心肌细胞,将为缺血性心脏病的治疗提供更广阔的前景。

英文摘要：

OBJECTIVE： To review the bionomics of adipose tissue-derived stem cells and its application in ischemic heart disease, analyze its deficiencies, list some problems to be resolved in the future, and then provide evidences for clinical treatment. DATA SOURCES： Relevant English articles of adipose tissue-derived stem cells and ischemic heart disease were searched in Blackwell, Elsevier and Pubmed databases published from 1980 to 2007 with the key words ＂bone mesenchymal stem cells, adipose derived stem cells, cardiomyocytes, ischemic heart disease＂. Meanwhile, a computer-based search was conducted in China Journal Full-text Database with the key words of ＂bone mesenchymal stem cells, adipose derived stem cells, cardiomyocytes, ischemic heart disease＂ published between 1980 and 2007. The relevant data were also consulted in libraries books by hand. STUDY SELECTION： The literatures were selected initially： ①bionomics of adipose tissue-derived stem cells, ②adipose tissue-derived stem cells for ischemic heart disease. Literatures with repetitive content were excluded. DATA EXTRACTION： Totally 57 articles were selected firstly, and the articles were excluded due to the repetition of the same research or unrelated with the subjects. The rest 41 articles were selected for the review references. DATA SYNTHESIS： There was similar bionomics of adipose tissue-derived stem cells and bone mesenchymal cells, and the cell-surface marker spectrum was also very similar. Source of adipose tissue was wide, and the materials were drawn conveniently. Stroma cells could be largely obtained. The cells were easy to culture and amplify. It found that without any induction the adipose tissue-derived stem cells cultured in vitro could differentiate into autorhythmic myocardial cells. The therapy of adipose tissue-derived stem cells for ischemic heart disease was possible. CONCLUSION： The material source and proliferation of adipose tissue-derived stem cells is superior to bone mesenchymal stem cells. Adipose t