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Diastereoselective addition of lithium enolate of γ-substituted α-diazoacetoacetate to N-sulfinyl imines
  • ISSN号：0023-074X
  • 期刊名称：《科学通报》
  • 时间：0
  • 分类：O623.626[理学—有机化学;理学—化学] TQ223.2[化学工程—有机化工]
  • 作者机构：[1]Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Minis- try of Education, College of Chemistry, Peking University, Beijing 100871, China
  • 相关基金：This paper is dedicated to Professor LIU YouCheng on the occasion of his 90th birthday. This work was supported by the National Natural Science Foundation of China （20832002, 20772003, 20821062）, the Ministry of Education of the People ＇s Republic of China, and National Basic Research Program of China （2009CB825300）.
作者： MO FanYang LI Fei WANG JianBo[1]
关键词： 烯醇, 酰亚胺, Wolff重排, 锂, 二羰基, 二取代, 手性, 催化, diazo compound, pyrrolidine, N-sulfinyl imine, rhodium, diastereoselective addition
中文摘要：

高度，到 chiral N 亚磺酰 imines 的代替的 -diazoacetoacetate 的锂 enolate 的 diastereoselective 增加被开发了。增加产品进一步受到导致相片的 Wolff 重新整理或 Rh (II ) 催化 intramolecular N-H 插入分别地负担得起 chiral 4,5-disubstituted 2-oxo 和 3-oxo pyrrolidines。

英文摘要：

Highly diastereoselective addition of lithium enolate of γ-substituted , ＆ WANG JianBo-diazoacetoacetate to chiral N-sulfinyl imines has been developed. The addition products were further subjected to photo-induced Wolff rearrangement or Rh（II）-catalyzed intramolecu- lar N-H insertion to afford chiral 4,5-disubstituted 2-oxo and 3-oxo pyrrolidines, respectively.

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期刊信息
  • 《科学通报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院
  • 主编：周光召
  • 地址：北京东黄城根北街16号
  • 邮编：100717
  • 邮箱：csb@scichina.org
  • 电话：010-64036120 64012686
  • 国际标准刊号：ISSN：0023-074X
  • 国内统一刊号：ISSN：11-1784/N
  • 邮发代号:80-213
  • 获奖情况:
  • 首届国家期刊奖,中国期刊方阵“双高”期刊,第三届中国出版政府奖
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  • 被引量:81792