心血管疾病是目前世界上死亡的首要原因之一,其分子机制未明。核因子κB(NF-κB)在心血管疾病中发挥着重要作用,参与免疫反应、炎症、细胞生存、分化和增殖等一系列生命活动,并影响许多心血管疾病的发生、发展,如动脉粥样硬化、心肌梗死、心力衰竭等。现就NF-κB在心血管疾病中的作用予以综述。
Cardiovascular diseases are still one of the primary causes of death worldwide,but the molecular mechanisms are still unknown.Nuclear factors κB(NF-κB)has plays an important role in cardiovascular disease,involved in a series of life activities including immunity,inflammation,cell survival,differentiation and proliferation,affecting incidence and development of many cardiovascular diseases such as atherosclerosis,myocardial infarction,and heart failure.Here is to make a review on the role of NF-κB in cardiovascular diseases.