中文摘要：

【目的】观察不同剂量柚皮苷对腰5脊神经结扎加切断（L5SNL）引起的神经病理性疼痛的抑制作用。【方法】利用行为学测试的方法,我们检测了口服柚皮苷对L5SNL大鼠50%机械刺激撤足阈值的影响。【结果】30,90,100mg/kg柚皮苷可显著提高L5SNL大鼠的50%机械刺激撤足阈值,10mg/kg无效。单次给药（30或90mg/kg）对大鼠50%机械刺激撤足阈值缓解作用可达6h左右,连续7天给予柚皮苷（30mg/kg,每天1次）其作用可持续至停药后4d。【结论】口服柚皮苷可缓解外周神经损伤引起的神经病理性疼痛。

英文摘要：

【Objective】 To investigate the effect of naringin at different doses on the neuropathic pain produced by lumbar 5 spinal nerve ligation （L5 SNL）.【Methods】 Using the method of behavioral test,we tested the 50% paw withdrawal threshold before and after intragastrical application of naringin in the rats with L5 SNL.【Results】 Naringin at 30,90,100 mg / kg but not at 10 mg / kg increased the 50% paw withdrawal threshold of L5 SNL rats significantly.Single application of Naringin （at 30 or 90 mg / kg） inhibited mechanical allodynia for around 6 hours,and the inhibitory effect persisted for 4 days after the cessation of the drug when naringin （30 mg / kg,daily） was consecutively applied for 7 days.【Conclusion】 Intragastrical of naringin could relieve the neuropathic pain produced by peripheral nerve injury.