中文摘要：

目的 探讨铝电解职业人群认知功能减退和周围血全基因组甲基化改变之间的关系。方法 采用横断面调查方法,以366名从事铝电解作业10年以上的工人为铝接触组,以102名面粉厂工人为对照组。2组人群均采用简易精神状态量表（MMSE）评价认知功能,采集周围血检测血清铝水平和全基因组甲基化率。铝接触组人群根据是否检出轻度认知功能障碍（MCI）分为MCI和非MCI亚组。结果 与对照组比较,铝接触组人群血清铝水平较高[中位数（M）：48.99vs29.17μg/L,P〈0.01],MMSE总分较低[（27.78±1.38）vs（29.10±1.77）分,P〈0.01],MCI检出率较高（11.75%vs2.94%,P〈0.01）,全基因组甲基化率较低[M：15.05%vs17.01%,P〈0.01]。铝接触组人群MMSE总分和全基因组甲基化率均随血清铝水平增加而下降（P〈0.05）。铝接触组人群MCI亚组全基因组甲基化率低于非MCI亚组[M：15.53%vs17.54%,P〈0.05]。多元线性逐步回归分析结果显示,铝电解职业人群MMSE总分与血清铝水平呈负相关（P〈0.05）,与全基因组甲基化水平呈正相关（P〈0.01）。结论 长期接触铝可以导致职业人群MCI,其认知水平和铝接触水平及周围血全基因组甲基化水平均有关联。

英文摘要：

Objective To analyze the correlation between the decreased cognitive function and whole-genome methylation change in peripheral blood in aluminium（ Al） electrolysis workers. Methods Using cross-sectional survey method,a total of 366 Al electrolysis workers with over 10 working years were selected as exposure group,and 102 workers without Al exposure in a flourmill were chosen as control group. The cognitive function of two groups were assessed with the MiniMental State Examination（ MMSE）. Peripheral blood was collected to detect the Al level in serum and the whole-genome methylation rate. According to the detection of mild cognitive impairment（ MCI）,the Al exposure group was divided into MCI subgroup and non-MCI subgroup. Results Compared with the control group,the Al level in serum of the Al exposure group was higher [Median（ M） ： 48. 99 vs 29. 17 μg / L,P〈0. 01],MMSE total scores were lower [（ 27. 78 ± 1. 38） vs（ 29. 10 ± 1. 77） scores,P〈0. 01],the incidence rate of MCI was higher（ 11. 75% vs 2. 94%,P〈0. 01）,the wholegenome methylation rate was lower [M： 15. 05% vs 17. 01%,P〈0. 01]. With the increase of Al level,Al exposed workers showed significant decrease in MMSE total scores and whole-genome methylation rate（ P〈0. 05）. In the Al exposure group,the whole-genome methylation rate of the MCI subgroup was lower than that of the non-MCI subgroup[M： 15. 53% vs 17. 54%,P〈0. 05]. Multivariate linear regression analysis showed that the MMSE total score was negatively correlated with the Al exposure level in Al exposure group（ P〈0. 05）,and positively correlated with the wholegenome methylation level（ P〈0. 01）. Conclusion Long-term Al exposure may cause MCI of Al exposed workers,the cognitive level is correlated with Al exposure level and the whole-genome methylation level.