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Preparation of Aminated Macroporous Polyvinyl Alcohol Resins and Evaluation for Bilirubin Adsorption

ISSN号：1004-0552
期刊名称：《中国生物医学工程学报：英文版》
时间：0
分类：R318.08[医药卫生—生物医学工程;医药卫生—基础医学]
作者机构：[1]The Key Laboratory of Biouctive Materials, Ministry of Education, Nankai University, Tianjin 300071, China, [2]Tianjin Medical University, Tianjin 300070, China
相关基金：Grant sponsor： National 863 Programme ; Grant number ： 2007 -AA- 04 Z234

作者： WANG Wei-chao[1], HANG Sheng-nan[2], HU Yue-han[1], XIE Hui[1], OU Lai-liang[2], YU Yao-ting[1], KONG De-ling[1], GU Han-qing[2]

关键词：胆红素, 生物材料, 大孔聚乙烯, 树脂, macroporous polyvinyl alcohol resins, aminated resins, bilirubin, adsor-bent , blood purification

中文摘要：

在现在的学习，我们准备了 macroporous 聚乙烯化合物的白酒祷告。一系列 bilirubin 吸附物被八个胺代理人的固定作为 ligands 产生到祷告。bilirubin 的吸附被评估由在 vitro 静态、动态的吸附测试。结果证明这些吸附物有优秀吸附效率和能力。在八 ligands， trimethylamine (TMA ) ， triethylamine (茶) 和 1,6- hexanediamine 之中() 显示出最高的吸附能力。吸附平衡能在半个小时被完成，并且 bilirubin 的吸附百分比直到 80% 。静态的电和恐水病的相互作用在 bilirubin 吸附起了主要作用，并且吸附被发现匹配单层模型。这些吸附物的优秀吸附在临床的处理显示他们的潜力。

英文摘要：

In the present study we prepared macroporous polyvinyl alcohol beads. A series of bilirubin adsorbents were generated by immobilization of eight amine agents to the beads as ligands. The adsorption of bilirubin was evaluated by in vitro static and dynamic adsorption tests. The results show that these adsorbents have excellent adsorption efficiency and capacity. Among the eight ligands, trimethylamine （TMA）, triethylamine （TEA） and 1,6- hexanediamine （HDA） showed the highest adsorption capacity. The adsorption equilibrium can be achieved in half an hour, and the adsorption percentage of bilirubin was up to 80%. Static electricity and hydrophobie interaction played the main role in bilirubin adsorption, and the adsorption was found to match the monolayer model. The excellent adsorption of these adsorbents indicates their potential in clinical treatment.