正链RNA病毒是家族非常庞大,可以感染多种动、植物及人的一类病毒。研究这类病毒的复制机理和调控方式对于阐明病毒的致病机制,以及研制新型抗病毒药物和疫苗等具有重要意义。RNA依赖性RNA聚合酶(RNA-dependent RNA polymerase,RdRp)是正链RNA病毒进行复制的关键蛋白酶,研究其结构与功能是了解病毒复制机理的前提和基础。本文即对近年来关于正链RNA病毒RdRp的结构与功能研究进展情况进行综述。
The positive-strand RNA viruses are composed of a large family that infect various animals,plants and human beings.Understanding on the replication and regulation mechanisms of RNA viruses is important to investigate pathogenesis and develop antiviral drugs and vaccines.The RNA-dependent RNA polymerase(RdRp) is a key enzyme responsible for the replication of positive-strand RNA viruses.This review focused on recent progress in research on structure and functions of RdRp.