中文摘要：

由对 thermoresponsive 聚合物的阶段转变温度的结束组的化学结构的影响启发了，我们表明了策略经由 thermoresponsive 聚合物片断的结束组的微妙的修正控制聚合物集会的 multi-responsiveness 并且为药交货揭示了它的潜在的应用程序。由发展，聚合物集会创作了 poly (脂肪族的酉旨) 作为是的内部核心和 thermoresponsive polyphosphoester 外部壳，我们证明 thermoresponsive polyphosphoester 片断的结束组控制了集会的表面性质并且进一步决定了刺激应答的行为。未修改的聚合物集会的阶段转变温度被他们的表面性质紧控制由于对响应环境刺激的结束组的恐水病的转变吸水(例如 pH 或轻照耀) 。对这些表面性质罐头由的外部控制由调整 thermoresponsive polyphosphoesters 的终端组的化学结构和作文维护了。

英文摘要：

Inspired by the influence of chemical structure of end groups on the phase transition temperature of thermoresponsive polymers,we demonstrated a strategy to control the multi-responsiveness of polymer assemblies via subtle modification of end groups of thermoresponsive polymer segments and revealed its potential application for drug delivery.By developing polymer assemblies composed of poly(aliphatic ester) as the inner core and thermoresponsive polyphosphoester as the outer shell,we showed that end groups of thermoresponsive polyphosphoester segments controlled the surface property of assemblies and further determined the stimuli-responsive behavior.The phase-transition temperatures of the unmodified polymer assemblies are tightly controlled by their surface properties due to the hydrophilic to hydrophobic transitions of end groups in response to an environmental stimulus (e.g.pH or light irradiation).External control over these surface properties can by asserted by adjusting the chemical structure and composition of the terminal groups of the thermoresponsive polyphosphoesters.