研究了三氟乙酸(TFA)对各种L-α-氨基酸催化环己酮与对硝基苯甲醛的不对称直接Aldol反应的影响。结果表明:在TFA作用下,所测试的绝大部分氨基酸的催化性能都有显著变化,多数情况下能提高收率和对映选择性;对非对映选择性的影响无明显规律。
Effects of TFA on the direct asymmetric Aldol reaction of cyclohexanone and 4-nitrobenzaldehyde catalyzed by different L-α-amino acids were systematically studied. For most amino acid catalysts, significant effects of TFA were observed on the catalytic efficacy, in many cases affording improved yield and enantioselectivity, albeit no obvious trend observed with the diastereoseletivity.