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中文摘要：
HSCs（hematopoietic stem cells,HSCs）具有自我更新和定向分化能力。电离辐射通过诱导HSCs细胞死亡使HSCs数量减少、诱导HSCs衰老引起HSCs自我更新能力的改变,以及诱导HSCs分化异常进而损伤HSCs,深入研究HSCs辐射损伤机制将为骨髓辐射损伤研究提供新思路。
英文摘要：
Hematopoietic stem cells （HSCs） has the potentiality to renew themselves and to differentiate into different lineages of blood cells. Exposure to ionizing radiation （IR） causes HSCs damage, the mechanisms include： induction of HSCs death that leading to the reduction in HSCs reserves, induction of HSCs senescence which impairs HSCs self-renewal capacity, and promotion of HSCs differentiation that changes the banlance of hematopoietic lineages. Mechanisms whereby IR damages HSCs will provide new opportunities for developing new strategies to mitigate IR-induced bone marrow（BM） suppression.
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