中文摘要：

以巯基乙酸为修饰剂合成高量子产率的CdTe量子点,并成功标记生物小分子17β-氨基雌二醇。紫外光谱、荧光光谱、红外光谱以及倒置显微镜照片分析表明CdTe量子点在活化剂N-羟基琥珀酰亚胺的作用下,通过表面的羧基与17β-氨基雌二醇的氨基以共价键结合,这为建立基于量子点探针的新型的药物筛选模型提供了实验基础。

英文摘要：

Water-soluble CdTe quantum dots（QDs） stabilized by thioglycolic acid（TGA） with high quantum yield were synthesized.And the small biomolecule 17β-amino-estradiol was marked successfully by CdTe QDs.The analysis of UV-Vis spectroscopy,fluorescence spectroscopy,infrared spectroscopy and inverted microscope photographs showed that the surface carboxyl of CdTe quantum dots conjugated with the amino of 17β-amino-estradiol through the activation of N-hydroxysuccinimide.17β-amino-estradiol marked by CdTe QDs successfully provided an experimental basis for new drug screening model.