中文摘要：

为了提高临床抗肿瘤药物的疗效,降低其毒副作用,本研究探讨以阿霉素（ADM）为模型药物,以聚氰基丙烯酸正丁酯（PBCA）为载体,通过乳化聚合法制备PBCA载药纳米微球并对其表征;利用红外光谱探讨载药纳米微球的结合机理,检测了PBCA载药纳米微球的体外释药性能;最后将PBCA载药纳米微球经十六烷基三甲基溴化铵对其表面改性后,利用化学键合方法在其表面修饰上转铁蛋白（Tf）,旨在实现药物的主动靶向性。通过L9（33）正交设计实验发现,优化后的载药纳米微球平均粒径为276.7 nm,平均包封率为（54.74±1.52）%,平均载药量为（26.07±1.63）%,分散性及成球性良好。另外体外释药实验表明,PBCA载药纳米微球具有良好的缓释性能和双相释药特性,符合双相动力学方程：Q=0.516 1＋36.02e（-t/6.151 2）＋5.87e（-t/1.61）（r=0.989 5）。

英文摘要：

In the interests of advancing clinical curative effect and reducing side-effect of antitumor drugs,this paper described adriamycin（ADM） as model drug,polybutylcyanoacrylate（PBCA） as drug delivery material,drug-loaded PBCA nanospheres was synthesized in emulsified solution and then characterizated.The conjunct mechanism of nanospheres were studied by FT-IR.The controlled-release of PBCA drug-loaded nanospheres in vitro were investigated as well.Furthermore,ADM-PBCA were surface modified by CTAB,and then targeted by transferrin via chemical bonding.The measurements of ADM-PBCA nanospheres were： the mean diameter was 276.7 nm,the mean encapsulation rate was（54.74±1.52）%,the mean loading was（26.07±1.63）%,the dispersancy and conglobation of nanospheres were fine.The release in vitro showed that,the PBCA drug-loaded nanospheres possessed the characterization of sustained-release and biophases-release,in accordance with the biophases kinetic equation： Q=0.516 1＋36.02e（-t/6.151 2）＋ 5.87e（-t/1.61）（r=0.989 5）.