中文摘要：

细胞因子信号转导抑制因子（suppressor of cytokine signaling,SOCS）是一类可由多种细胞因子诱导产生,又能通过多种途径对细胞因子的信号转导进行负向调节的蛋白质分子。众多研究发现SOCS蛋白家族是一个非常重要的可以负向调节JAK/STAT信号通路的分子家族。本文将着重阐述介绍SOCS家族在炎症和自身免疫性疾病中的作用。

英文摘要：

The suppressor of cytokine signalling is a protein family which can be induced by various cytokines. But, it can negatively regulate the signal transduction of the cytokines through a variety of ways. Many studies were found that the SOCS family played an important role in negatively regulating the JAK/STAT signalling pathway. In this review, we will introduce the relationship between the SOCS and inflammation, autoimmune diseases.