中文摘要：

利用荧光光谱法研究了环丙沙星与母体β-环糊精（β-CD）及其2种修饰衍生物羟丙基-β-环糊精（Hp-β-CD）、甲基-β-环糊精（Me-β-CD）形成的超分子体系,同时测定了3种超分子体系的猝灭常数和热力学参数.结果表明：环丙沙星与3种环糊精之间常温下均形成稳定的包合物;环丙沙星与3种环糊精包结过程中ΔG〈0和ΔH〈0,这说明环丙沙星与3种环糊精的包结能够自发进行而形成超分子体系,且反应为放热过程.通过对3种环糊精与环丙沙星的热力学数包结能力进行了比较,初步探讨了作用机理和影响包结能力大小的可能因素.

英文摘要：

The supramolecular systems of ciprofloxacin with fl-CD, Me-fl-CD and Hp-fl-CD have been studied by fluorescence spectroscopy respectively, and the binding constants and the thermodynamic parameters of ciprofloxacin with three above mentioned CDs were all determined by fluorescence spectroscopy at different temperatures. The experimental result showed the interaction between ciprofloxacin and three CDs occurred and new supramolecular systems were formed. Inclusion ability between ciprofloxacin and three CDs was compared. The AG and AH of the three supramolecular systems all reduced, the supramolecular systems of ciprofloxacin with three CDs formed spontaneously. The inclusion ability of modified Me-β-CD and Hp-β-CD with ciprofloxacin is stronger than that of native β- CD.