中文摘要：

肾素-血管紧张素系统（RAS）在维持肾脏生理功能及肾脏疾病的发生、发展过程中发挥着重要作用,血管紧张素Ⅱ（AngⅡ）是RAS的主要效应分子,被认为是肾脏疾病进展的主要危险因子.肾脏可产生AngⅡ,如足细胞产生AngⅡ及表达其受体.肾脏局部的AngⅡ可以通过一系列非血流动力学途径介导足细胞损伤,如影响细胞裂孔隔膜结构、细胞骨架重排、细胞表型转换与细胞肥大、细胞凋亡、细胞自噬等,提示肾脏局部的AngⅡ与足细胞病变之间有着密切联系.

英文摘要：

Renin-angiotensin system （RAS） plays an important role in maintaining kidney function and in the oc-currence, development of renal diseases. Angiotensin Ⅱ （ Ang Ⅱ ） , a key effector of RAS, is considered as an important risk factor in the progression of kidney diseases. Kidneys can produce Ang Ⅱ , for example, podocytes produce Ang Ⅱ and expres- ses its receptor. Kidney Ang Ⅱ can lead to podocyte lesions through a series of non - hemodynamic ways, such as influencing cell slit diaphragm structure, cytoskeletal rearrangement, cell phenotype conversion and cell hypertrophy, apoptosis, autoph-agy, etc. suggesting that rennin Ang Ⅱ is closely associated with podocyte lesions.