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中文摘要：
目的应用软件和在线网络分析Eg95的蛋白二级结构,预测B细胞表位和T细胞表位,为确定和筛选优势表位,研制安全、高效的表位疫苗奠定基础。方法采用DNAStar软件和在线网站IEDB、SYFPEITHI等对Eg95的B细胞表位和T细胞表位进行预测。结果 Eg95存在潜在的抗原表位,B细胞表位区域：16-38,41-48,50-67,68-90,92-100,103-113,120-132。分值高的T细胞表位区域：6-14,14-22,48-56,4-12,98-106,142-150,146-154。结论运用生物信息学方法确定Eg95存在7个抗原表位,对进一步研究Eg95的抗原性和研发优势表位疫苗具有重要的意义。
英文摘要：
The protein secondary structure was analyzed by TMHMM Sever2.0 and SOPMA Sever,and B cell and T cell epitopes of Eg95 were predicted by DNAStar,IEDB and SYFPEITHI.Many distinct antigenic epitopes of Eg95 were identified by computation,and the possible B cell epitopes of which were in the regions of 16-38,41-48,50-67,68-90,92-100,103-113,and 120-132.The high score of T cell epitopes were in the regions of 6-14,14-22,48-56,4-12,98-106,142-150,and 146-154.These results indicated that there are 7 antigen epitopes in Eg95 antigen determined by bioinformatics methods,which are significant in the further research of Eg95 antigenic and development of dominant epitope vaccine.
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同项目期刊论文
The prediction of T- and B-combined epitope and tertiary structure of the Eg95 antigen of Echinococc
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