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变应性鼻炎与精神心理紊乱
  • ISSN号:1673-4106
  • 期刊名称:《国际耳鼻咽喉头颈外科杂志》
  • 时间:0
  • 分类:Q-332[生物学] TQ46[化学工程—制药化工]
  • 作者机构:[1]Department of Otorhinolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China, [2]Key Laboratory of Otolaryngology Head and Neck Surgery,Ministry of Education of China,Beijing 100005,China, [3]Beijing Institute of Otolaryngology,Beijing Municipal Health Bureau,Beijing 100005,China
  • 相关基金:This work was supported by grants of the National Key Technology R&D Program from the Ministry of Science and Technology of China (No. 2007BAI18B15), National Natural Science Foundation of China (No. 30872846), Beijing Natural Science Foundation (No. 7072017) and the Program for New Century Excellent Talents in University (No. NCET-0600185)HAN De-min and ZHANG Luo contributed equally to this study.
中文摘要:

过敏鼻炎(AR ) 的背景客观评估在 vivo 并且在 vitro 测试要求。在 vitro,测试是重要的在 multi-allergen-sensitive 病人帮助或保证主要变应原。这研究的目的是评估浆液的实用程序特定的在有在作为 AR 的诊断引用标准联合积极皮肤刺测试( SPT )和临床的历史的中国 population.Methods 的多变应原的 AR 病人的诊断的 IgE ( slgE ),我们估计了在 85 个 AR 病人之中响应 7 很经常的变应原生产的 slgE 的集中,用在有积极 SPT 结果和变应原特定的鼻音症状的 85 个个人之中的 UniCAP 试金 system.Results , s 用一个班的积极截止价值基于临床的诊断和 SPT 结果 1 个分数,执行很好的 CAP 测试和为不同变应原的敏感从 0.5 (巨大的豕草属)到 0.91 ( Dermatophagoides pteronyssinus ( Der p )和 Dermatophagoides farinae ( Der f ),当特性从 0.93 时( Der f )到 1.0 (动物头发, Derp 和艾蒿)。截止分数是什么时候,适应了班 2,当留下估计了项目时,敏感总的来说显示出增加包括特性,积极的预兆的值,否定的预兆的值和效率,证明生长得很好的浆液 slgE 测试的不能接受的 decline.Conclusions 与 SPT 相关很好。给一个类 1 为 SPT 结果的确实截止比一个类好为估计 AR 的 2 背景诊断价值。

英文摘要:

Background Objective evaluation of allergic rhinitis (AR) requires in vivo and in vitro tests. In vitro tests are important to assist or ensure the main allergens in multi-allergen-sensitive patients. The aim of this study was to evaluate the utility of serum specific IgE (slgE) in the diagnosis of AR patients with multi-allergens in the Chinese population.Methods Combining a positive skin prick test (SPT) and clinical history as the diagnostic reference criteria of AR, we estimated concentrations of slgE produced in response to the 7 most frequent allergens among 85 AR patients, using the UniCAP assay system.Results Among 85 individuals with positive SPT results and allergen-specific nasal symptoms, slgE concentration correlated well with SPT classes among all the tested allergens. Based on a clinical diagnosis and SPT results using a positive cut-off value of a class 1 score, the CAP test performed well and the sensitivity for different allergens ranged from 0.5 (giant ragweed) to 0.91 (Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f), while specificity ranged from 0.93 (Der f) to 1.0 (animal hair, Derp and mugwort). When the cut-off score was adjusted to class 2, the sensitivity showed an increase overall while the remaining assessed items, including specificity, positive predictive value, negative predictive value and efficiency, showed an unacceptable decline.Conclusions Well-established serum slgE tests correlated well with SPTs. Setting a class 1 cut-off for positivity of SPT results was better than a class 2 setting for assessing the AR diagnostic value.

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期刊信息
  • 《国际耳鼻咽喉头颈外科杂志》
  • 中国科技核心期刊
  • 主管单位:国家卫生部
  • 主办单位:中华医学会 北京市耳鼻咽喉科研究所
  • 主编:
  • 地址:北京市崇内后沟胡同17号
  • 邮编:100005
  • 邮箱:entbjb@163.com
  • 电话:010-65596373
  • 国际标准刊号:ISSN:1673-4106
  • 国内统一刊号:ISSN:11-5395/R
  • 邮发代号:2-610
  • 获奖情况:
  • 国内外数据库收录:
  • 中国中国科技核心期刊
  • 被引量:1429