中文摘要：

目的 探讨可溶性Mer受体酪氨酸激酶（sMerTK）在SLE患者血清检测中的临床意义.方法 采用ELISA法分别检测101例SLE与96例疾病对照组患者,及62名健康对照组血清中sMerTK水平;分析比较其与SLE各种临床表现、实验室指标及疾病活动度的关系.采用t检验χ^2检验及Spearman相关分析法进行数据分析.结果 SLE患者血清中sMerTK水平[（10.6±6.0）ng/ml]明显高于疾病对照组[（4.4±2.0） ng/ml]（t=9.704,P＜0.01）及健康对照组[（2.8±2.5）ng/ml] （t=1 1.505,P＜0.01）.血清sMerTK浓度与SLE患者的性别、年龄、病程无关,与白细胞（r=-0.236,P=0.017）、血红蛋白（r=-0.354,P＜0.01）、血小板（r=-0.310,P=0.002）水平呈负相关.在伴有LN患者中,血清sMerTK水平[（11±6） ng/ml]高于不伴有LN的SLE患者[（9±6）ng/ml],差异具有统计学意义（t=2.071,P=0.041）.sMerTK水平的高低与LN患者尿蛋白定量（24 h）（r=0.293,P=0.013）、血清肌酐（r=0.250,P=0.035）及肾小球滤过率（r=-0.201,P=0.045）的水平有相关性,与血清补体C3 （r=-0.447,P＜0.01）及补体C4（r=-0.357,P＜0.01）水平呈负相关,与抗dsDNA抗体（r=0.360,P＜0.01）、抗核小体抗体（AnuA） （r=0.264,P=0.016）及SLEDAI积分（r=0.473,P＜0.01）呈正相关.结论 SLE患者血清sMerTK水平明显升高,可能与患者的血液系统损害及LN相关,并提示狼疮病情活动.

英文摘要：

Objective To investigate the clinical significance of soluble Mer receptor tyrosine kinase （sMerTK） in patients of systemic lupus erythematosus.Methods sMerTK was detected in the serum of 101 SLE patients,96 disease controls and 62 healthy controls （HC） by sandwich enzyme-linked immunosorbent assay （ELISA）.The relationships between the serum levels of sMerTK and clinical manifestations,laboratory parameters,disease activity were investigated in SLE patients.Comparisons between groups were tested by t-test and χ^2 test,Correlation of parameters were analyzed by Spearman method.Results sMerTK levels in SLE patients [（10.6±6.0） ng/ml] was significantly higher than disease controls [（4.4±2.0） ng/ml] （t=9.704,P〈0.01） and healthy controls [（2.8±2.5） ng/ml] （t=11.505,P〈0.01）.The concentrations in SLE patients were independent of gender,age and disease duration.The levels of sMerTK were negatively correlated with white blood cell （r=-0.236,P=0.017）,hemaglobin（r=-0.354,P〈0.01）,platelet values （r=-0.310,P=0.002）.Compared with the patients without lupus nephritis （LN）[（9±6） ng/ml],patients with LN had higher concentrations in serum [（11±6） ng/ml],and the difference was statistically significant （t =2.071,P=0.041）.In addition,sMerTK levels were also correlated with 24 h-urinary protein level （r=0.293,P=0.013）,serum creatinine （r=0.250,P=0.035） and e-GFR （r=-0.201,P=0.045）.Furthermore this study indicated that sMerTK was negatively correlated with C3 （r=-0.447,P〈0.01） and C4 （r=-0.357,P〈0.01）level,but positively correlated with anti-dsDNA antibody titers （r=0.360,P〈0.01）,anti nucleosome antibody （AnuA） （r=0.264,P=0.016） and SLEDAI （r=0.473,P〈0.01）.Conclusion sMerTK level is increased in SLE patients.The concentration may associate with hematology changes and lupus nephritis.It may be an indicator of disease activity.