中文摘要：

目的探讨激素治疗溃疡性结肠炎（UC）的黏膜愈合程度与其预后的相关性。方法对接受激素治疗（n=86）的UC患者随访2年。首先在治疗6个月后对其进行早期临床疗效评价（Powel—Tuck，PW）和组织病理学分级，并将患者分为完全应答（A组：PT，0～1分；病理分级，0级）、部分应答（B组：PT，0～1分；病理分级，I～Ⅱ级）和无应答（c组：PT≥2分；病理分级≥Ⅲ级）。随后对其疾病复发、再入院、结肠手术、免疫抑制剂使用等预后情况进行追踪，评估早期治疗UC的黏膜愈合程度和其后期预后的相关性。结果2年后，完全（A组）和部分应答（13组）患者预后情况在以下方面出现差异：再人院率[A组27．5％ vs 13组44．1％；P=0．018；OR=2．24；95％CI（1．11～3．98）]、免疫抑制治疗[A组7．5％VSB组26．5％；P=0．008；OR=5．67；95％CI（3．24～8．93）]、结肠切除术[A组0．00％vs B组17．6％；P=0．035；OR=5．43；95％CI（2．14—7．64）]。结论激素治疗UC早期达到黏膜愈合与其后期良好的预后存在明显的正相关。

英文摘要：

Objective To evaluate the relationship between mucosal healing and outcomes in ulcerative colitis （UC） after treatment with corticosteroids. Methods Patients with UC who were prescribed corticosteroid therapy （n = 86） were followed up for 2 years. They were evaluated by clinical （Powel-Tuck, PT） and histopathology grading after 6 months, outcomes at 6 months （ early response） were used to identify patients with complete （ group A ： PT, 0 - 1 ; his- topathology grading, 0） , partial （ group B ： PT, 0 - 1 ; histopathology grading, Ⅰ-Ⅱ） , or no response （group C ： PT 2 ; histopathology grading≥Ⅲ ）. The association between mucosal healing and late outcomes was assessed. Results After 2 years, there were significant differences between complete and partial responders in the rates of hospitalization [ 27.5 % in group A vs 44.1% in group B ; P = 0.018 ; OR = 2.24 ;95 % CI （ 1.11 - 3.98 ） ], immunosuppression therapy [（7.5% in group A vs26.5% in group B; P=0.008; OR=5.67;95%CI（3.24-8.93）] , coleetomy [0.00% in group A vs 17.6% in group B ; P = 0. 035 ; OR = 5.43 ;95% CI（2.14 - 7.64） ]. Conclusion Mucosal healing after corticosteroid therapy is associated with late outcomes in UC.