中文摘要：

c AMP反应元件结合蛋白（c AMP responsive element binding protein,CREB）作为细胞内重要的转录因子,调控靶基因的表达进而影响肿瘤的发生发展。文献表明,mi RNA作为原癌基因或抑癌基因参与调控肿瘤的机制之一,与CREB密切相关。该文结合目前的研究成果,对CREB及其相关mi RNAs独立和联合效应在肿瘤发生发展中的作用及其分子机制进行综述。

英文摘要：

Cyclic AMP responsive element-binding protein（CREB） is a proto-oncogenic transcription factor, and generally affects the tumorgenesis by regulating the expression of targeted genes. Recent reports showed that the mechanism of mi RNAs, as proto-oncogenes or suppressor genes in tumorigenesis, was tightly related with CREB. Combined with present research, this review summarized the independent and interactive effects of transcription factor CREB and its related mi RNAs in tumorigenesis.