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外消旋木榄醇甲的简捷合成
  • ISSN号：0567-7351
  • 期刊名称：《化学学报》
  • 时间：0
  • 分类：O625.42[理学—有机化学;理学—化学] TQ174.759[化学工程—陶瓷工业;化学工程—硅酸盐工业]
  • 作者机构：[1]中国药科大学新药研究中心,南京210009, [2]中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海200032
  • 相关基金：国家自然科学基金（Nos.20372075,20321202,20672129,20621062,20772143）、中国科学院知识创新工程（No.KJCX2.YW.H08）资助项目.
作者： 吴建忠[1,2], 甄志彬[2], 张奕华[1], 伍贻康[2]
关键词： FRIEDEL-CRAFTS反应, 桥环, 天然产物, 全合成, 缩酮, Fredel-Crafts reaction, bridged ring, natural product, total synthesis, ketal
中文摘要：

报道了天然产物木榄醇甲的一种高效合成方法．目标分子结构中的饱和碳链部分以廉价的化工原料4-羰基戊酸（国内俗称“左旋糖酸”或“果糖酸”）为起始原料合成．经Wittig反应与间甲氧基苯甲醛相连接后，对所形成的碳-碳双键进行环氧化并在苄位进行选择性脱氧形成关环前体．关键的桥环部分结构的建立利用了由缩酮为烷化剂的分子内Friedel-Crafts反应．

英文摘要：

A highly efficient synthesis of racemic bruguierol A （a natural product） is presented. The key bridged cyclic framework was constructed using an intromolecular Friedel-Crafts alkylation with a ketal as the alkylating agent developed in our group several years ago.

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期刊信息
  • 《化学学报》
  • 北大核心期刊（2014版）
  • 主管单位:中国科学院
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：周其林
  • 地址：上海市零陵路345号
  • 邮编：200032
  • 邮箱：hxxb@sioc.ac.cn
  • 电话：021-54925085
  • 国际标准刊号：ISSN：0567-7351
  • 国内统一刊号：ISSN：31-1320/O6
  • 邮发代号:4-209
  • 获奖情况:
  • 首届国家期刊奖,第二届国家期刊奖提名奖,中国期刊方阵“双高期刊”
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:28694