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心脏转录因子GATA4与心房颤动的关系
  • ISSN号：1009-7236
  • 期刊名称：《心脏杂志》
  • 时间：0
  • 分类：R541.75[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构：[1]上海市医学科学技术情报研究所,上海200031, [2]上海交通大学附属胸科医院心内科、心血管研究室、中心实验室,上海200030
  • 相关基金：国家自然科学基金项目资助（30570768,81070153,81270161）;上海市自然科学基金项目资助（10ZR1428000）
作者： 丁媛媛[1], 王倩[2], 杨奕清[2]
关键词： 心房颤动, 遗传学, 心脏转录因子, atrial fibrillation , genetics , transcriptional factor
中文摘要：

心脏转录因子GATA4是一种在心脏中大量表达的锌指转录因子，在心血管发育、心肌重构与肌细胞凋亡方面发挥着重要的生理作用，GATA4基因突变可导致多种先天性心脏病。近年来的研究显示，GATA4基因突变也可导致心房颤动（AF）。本文拟就GATA4的生理功能及其与AF的关系进行综述，旨在便于理解AF新的分子机制，从而有助于AF的早期预防和个体化治疗。

英文摘要：

GATA4 is a zinc finger-containing transcriptional factor highly expressed in the heart and playsan important physiological role in cardiovascular development, myocardial remodeling and cellular apopto-sis. Mutations in the GATA4 gene have been implicated in various kinds of congenital heart diseases.Recent studies demonstrated that GATA4 mutations also lead to atrial fibrillation （AF）. In this paper thephysiological function of GATA4 and its association with AF are reviewed for a better understanding of thenovel molecular mechanism involved in the pathogenesis of AF and the early prophylaxis and personalizedtreatment of AF.

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先天性房间隔缺损相关GATA6基因新突变的识别
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期刊信息
  • 《心脏杂志》
  • 中国科技核心期刊
  • 主管单位:第四军医大学
  • 主办单位:第四军医大学 中国保健医学会心脏学会 中国医药信息学会心功能学会
  • 主编：裴建明
  • 地址：西安市长乐西路169号
  • 邮编：710033
  • 邮箱：xinzang@fmmu.edu.cn
  • 电话：029-84774525
  • 国际标准刊号：ISSN：1009-7236
  • 国内统一刊号：ISSN：61-1268/R
  • 邮发代号:52-131
  • 获奖情况:
  • 国家科技部中国科技论文统计源期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,中国中国科技核心期刊
  • 被引量:8972