中文摘要：

目的：探讨滁菊总黄酮对大鼠脑缺血再灌注损伤的保护作用。方法：将48只SD大鼠随机分为6组,假手术组、模型组、滁菊总黄酮组（40、80和160 mg/kg）、尼莫地平组,每组8只,腹腔注射给药。采用线栓法阻塞大鼠右侧大脑中动脉,制备大鼠脑缺血再灌注损伤模型,缺血2 h,再灌注24 h,进行神经行为评分、脑组织含水量测定、脑梗死体积测定、脑组织丙二醛（MDA）含量测定。结果：40、80和160 mg/kg滁菊总黄酮可降低大鼠脑组织含水量、减小脑梗死体积、降低脑组织MDA含量（P〈0.05或P〈0.01）;160 mg/kg的滁菊总黄酮可以降低大鼠的神经行为评分（P〈0.01）。结论：滁菊总黄酮对大鼠脑缺血再灌注损伤具有保护作用,可能与其抗氧化活性有关。

英文摘要：

AIM： To study the protective effects of total flavonoids of Chuzhou chrysanthemum （ TF- CC） against cerebral ischemia reperfusion injury in rats. METHODS： 48 SD rats were randomly as- signed into 6 groups of sham operation group, model control group, nimodipine group, TFCC 40, 80 and 160 mg/kg groups, with 8 rats in each group, which employed intraperitoneal administration. The ische- mic model was established with line embolism to block the middle cerebral artery of rats, with 24- hours-reperfusion after 2-hours-ischemia. 24 hours after modeling, the protective effect of TFCC was de- termined by behavioral neurological damage scores, water content of brain tissue, cerebral infarction volume. The content of malondi-aldehyde （MDA） in brain tissue were measured. RESULTS ：40, 80 and 160 mg/kg TFCC can reduce water content of brain tissue and cerebral infarction volume, and decrease the content of MDA in brain tissue （P 〈 0.05 or P 〈0.01 ） ; 160 mg/kg TFCC reduced neurobehavior- al score of rats （P 〈 0.01 ）. CONCLUSION ： TF- CC has a protective effect on cerebral ischemia reperfusion injury in rats, the effect may be associat- ed with its antioxidant activity.