中文摘要：

在体液、组织、生物界面等生物介质中广泛存在着自发形成的金属基生物微粒，其中包括在体内原位生成的和异位转化的内源性微粒，也包括外源性微粒在体内被修饰转化所产生的次生微粒。这些在体内形成的微粒的粒径在纳米至微米级之间，它们大都参与生理、病理和毒理过程。但是目前缺乏对它们的生物效应与其形成、结构、性质相关性的研究。本文列举了有关金属基生物微粒的诸多现象和对它们的初步认识，提出了这方面有待解决的问题，这方面的研究结果将对环境、健康、疾病控制等领域的研究提供新思路。

英文摘要：

Spontaneously formed metal-based bioparticles, such as those formed in situ and intrinsic particles transformed ex situ, as well as in vivo modified and transformed extrinsic particles, are often present in the biogical media including body fluids, tissues and biointerfaces. The size of these particles are between nano- and micro- meters. Most of them are involved in the physiological, pathological and toxicological processes. Up to now, however, there is a lack of research on the relationship between the biological effects and the formation, structure and properties of these particles. The present article lists some facts and preliminary understanding about these metal-based bioparticles. Some research areas to be investigated are also proposed. The findings in these areas may provide the insight into the studies on the environment, health, disease control and so on.