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中文摘要：
经前期综合征（PMS）是育龄期女性常见多发病。从肝疏泄太过致肝气上逆和疏泄不及致肝气郁结的基本病机出发,临床应用调肝法治疗PMS疗效显著,但机制不明。近年来,基于对大量调肝方药对应激性海马神经元损伤的保护性作用研究资料分析和MAPK途径是神经损伤修复的重要信号转导途径认识,结合我们前期发现,PMS发生发展的重要调节中枢在海马等脑区,治疗PMS肝气逆证的经前平颗粒可调节MAPK信号通路中JIK等若干信号分子的表达,提示我们MAPK信号通路活性状态可能与PMS发病机制密切相关,但目前国内外缺乏相关研究资料。因此,对MAPK信号通路与PMS发病机制相关性进行概述,可为进一步探讨PMS神经生化方面的微观机制提供参考。
英文摘要：
Premenstrual syndrome is the commonly and frequently encountered disease of child - bearing period women. Liver-qi invasion as well as liver - qi depression is its major syndrome. Although the PMS pathogenesis is not clearly understood, liver- regulating method has obvious effect. Most of the researches have focused on the MAPK signal pathway which is closely linked with the occurrence and repair of nervous system injury. But it is short of related studies about pathogenesis of PMS and MAPK signal pathway until now. It is well known that regulating liver formula can protect hippocampus against the stressed injury. PMS liver - qi invasion regulating center is located in hippocampus. Research has shown that regulating liver formula Jingqianping Granule can regulate JIK and other important genes expressions of MAPK pathways. These findings suggest that the abnormal ac- tive state of MAPK pathways is closely related to the pathogenesis of PMS, but there is lack of correlative research information un- til now. Here is to introduce correlation between MAPK pathways and PMS pathogenesis, with expectation to provide references on neural and biochemical micromechanism for PMS.
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