肺和呼吸道构成了宿主免疫系统与外界环境之间的一个脆弱的接触面,维持局部组织的免疫稳态至关重要。CD200/CD200R已被证实是一优先表达于肺组织的免疫调控系统,文章对CD200/CD200R及其分子调控机制相关研究作一综述。
Lung tissue and respiratory tract constitute a fragile interface between the host immune system and the exterior environment. Fine control of immunological homeostasis in this unique mieroenvironment is central to survival. CD200/ CD200R has proved to be an immune -regulating molecular pair preferentially expressed on the lung tissues. This paper presents a critical review of the function of CD200/CD200R pathway and its molecular mechanism.