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Prognostic factors for late mortality after liver transplantation for benign end-stage liver disease
  • 期刊名称:中华医学杂志:英文版
  • 时间:0
  • 页码:4229-4235
  • 分类:Q78[生物学—分子生物学] S858.9[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
  • 作者机构:[1]Liver Transplantation Center, Third Affiliated Hospital of SunYat-sen University, Guangzhou, Guangdong 510630, China, [2]Guangdong Provincial Key Laboratory of Liver Disease,Guangzhou, Guangdong 510630, China
  • 相关基金:This study was supported by grants from the Major State Basic Research Development Program (973 Program) of China (No. 2009CB522404), the National Natural Science Foundation of China (No. 30772044, 30801112, 30972914, 30972915), the Sci-tech Research Development Program of Guangdong Province (No. 2010B050700003), and the Guangdong Natural Science Foundation (No. 9251008901000020).
  • 相关项目:间充质干细胞对肝癌细胞及肝癌微环境的作用研究
中文摘要:

背景正在增加在研究在这些 patients.However 的早死亡上集中了的肝 transplantation.Many 以后熬过超过一年的病人的数字,影响长期的幸存的因素不是充分, understood.This 学习试图评估预言长期的幸存的预示的因素并且为改进为良性的结束阶段肝 diseases.Methods 经历了肝移植的病人的幸存结果探索措施原因近来死亡在以后

英文摘要:

Background There are increasing numbers of patients who survive more than one year after liver transplantation. Many studies have focused on the early mortality of these patients. However, the factors affecting long-term survival are not fully understood. This study aims to evaluate prognostic factors predicting long-term survival and to explore measures for improving the survival outcomes of patients who underwent liver transplantation for benign end-stage liver diseases. Methods The causes of late death after liver transplantation and potential prognostic factors were retrospectively analyzed for 221 consecutive patients who underwent liver transplantation from October 2003 to June 2008. Twenty-seven variables were assessed using the Kaplan-Meier method, and those variables found to be univariately significant at P〈0.10 were entered into a backward step-down Cox proportional hazard regression analysis to identify the independent prognostic factors influencing the recipients' long-term survival. Results Twenty-eight recipients died one year after liver transplantation. The major causes of late mortality were infectious complications, biliary complications, and Hepatitis B virus recurrence/reinfection. After Cox analysis, the five remaining co-variables were: age, ABO blood group, cold ischemia time, post-infection region, and biliary complications. Conclusions The major causes of late mortality were infection, biliary complications and Hepatitis B virus recurrence/reinfection. Five variables (Age, ABO blood group, cold ischemia time, infection, and biliary complications) had significant impacts on patient survival.

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