中文摘要：

目的：探讨抗P-选择素（P-selectin）及血小板糖蛋白Ⅱb/Ⅲa（GPⅡb/Ⅲa）抗体测定在鉴别特发性血小板减少性紫癜（ITP）和原发性干燥综合征（pSS）伴血小板减少鉴别诊断中的意义。方法采用ELISA法分别测定40例ITP患者，36例pSS伴血小板减少患者及40名正常人血浆中的抗P-selectin及GPⅡb/Ⅲa抗体。结果 pSS伴血小板减少组、ITP组抗P-selectin及GPⅡb/Ⅲa抗体水平及阳性率均高于正常对照组（P＜0.01）；pSS伴血小板减少组抗P-selectin抗体水平及阳性率显著高于ITP组（P＜0.01）；而pSS伴血小板减少组抗GPⅡb/Ⅲa抗体水平及阳性率与ITP组比较差异无统计学意义（P＞0.05）。结论抗P-selectin及GPⅡb/Ⅲa抗体测定在ITP和pSS伴血小板减少鉴别诊断中有显著的临床意义。

英文摘要：

Objective To study the clinical signifi cance of determining anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa （GPⅡb/Ⅲa） antibodies in the differential diagnosis of idiopathic thrombocytopenic purpura （ITP） and primary Sjgren Syndrome （pSS） with thrombocytopenia.Methods Plasma anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa antibodies in 40 patients with ITP, 36 pSS patients with thrombocytopenia and 40 normal individuals were detected by ELISA method.Results The level of anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa antibodies in patients with ITP and pSS with thrombocytopenia was much higher than that in the normal group （P〈0.01）, the level and positive rate of anti-P-selectin antibodies in pSS patients with thrombocytopenia were much higher than that in ITP （P〈0.01）. There was no difference of the level and positive rate of anti-platelet glycoproteinⅡb/Ⅲa antibodies between pSS patients with thrombocytopenia and ITP （P〉0.05）.Conclusion Detecting anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa antibodies might be helpful for differential diagnosis of ITP and pSS patients with thrombocytopenia.