东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

Mechanism of Incompatible Herb Pairs, Panax ginseng and Veratrum nigrum L,： Material Basis and Metabolic Profiles of Ginsenosides in Rat Intestinal Bacteria

ISSN号：1001-604X
期刊名称：《中国化学：英文版》
时间：0
分类：S858.236.6[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医] TS202.3[轻工技术与工程—食品科学;轻工技术与工程—食品科学与工程]
作者机构：[1]National Center of Mass Spectrometry in Changchun & Jilin Province, Key Laboratory of Chinese MedicineChemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, [2]Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
相关基金：This work was supported by National Basic Research Program of China （973 Program, Nos. 2011CB505300, 2011CB505305） and Jilin Province Science and Technology Projects of Traditional Chinese Medicine （No. 2014-ZD31）.

作者： Xiudong Yang[1], Xue Li[1], Ying Xu[2], Zifeng Pi[1], Na Lin[2], Zhiqiang Liu[1], Fengrui Song[1]

关键词：人参皂苷, 代谢特征, 肠道菌群, 不相容, 藜芦, 机制, 物质基础, 大鼠, Panax ginseng, Veratrum nigrum L., rat intestinal bacteria, incompatibility, UPLC-MS

中文摘要：

在繁体中文药理论，人参属人参和 Veratrum nigrum L。是重要不兼容的植物对。在老鼠的新陈代谢上的主要部件和影响的内容变化上的研究肠的细菌是有用的理解这的不兼容的机制植物对。在这研究，人参皂甙和他们的 metaboltic 的内容变化在 P 的摘录介绍。P 的人参和相容性。有 V 的人参。nigrum L。(G-V ) 用 electrospray 电离团 spectrometry (ESIMS ) 和 UPLCMS ⁿ, 分别地。大多数人参皂甙的相对内容在 G-V 的摘录被减少。而且，人参皂甙 Rb ₁, Rb ₂, Rc 和 Rd 能在老鼠被使产生代射变化到 Rd， F2 和 C-K 肠的细菌。在在 10:5， 10:7 和 10:10 和人参皂甙 Rb ₁, Rb ₂ 的新陈代谢的率的比率的 G-V 摘录的 Rb ₁, Rb ₂ 和 Rc 和到 Rd 的 Rc 的新陈代谢的速度，到在所有相容性摘录的 F2 的 Rd 在 P 是比那低的。人参摘录。在结论，这研究说明了机制由相对内容的比较和在 P 的相容性以后的人参皂甙的新陈代谢的侧面减少效果。人参和 V。nigrum L。

英文摘要：

In traditional Chinese medicine theory, Panax ginseng and Veratrum nigrum L. is an important incompatible herb pair. Studies on the content variation of main components and the influences on the metabolism in rat intestinal bacteria are useful to understand the mechanism of incompatibility of this herb pairs. In this study, the content variation of ginsenosides and their metaboltic profiles in the extracts of P. ginseng and compatibility of P. ginseng with V. nigrum L. （G-V） were investigated using relative quantitative method of electrospray ionization mass spec- trometry （ESI-MS） and UPLC-MSn, respectively. The relative contents of most ginsenosides were reduced in the extract of G-V. Furthermore, ginsenosides Rbt, Rb2, Rc and Rd could be metabolized to Rd, F2 and C-K in rat in- testinal bacteria. The metabolic speeds ofRbl, Rb2 and Re in the G-V extracts at ratios of 10 ： 5, 10 ： 7 and 10 ： 10 and the metabolic rates of ginsenosides Rbb Rb2 and Rc to Rd, Rd to F2 in all compatibility extracts were lower than that in the P ginseng extract. In conclusion, this study illustrated the mechanism of effect-reducing by comparison of the relative contents and metabolic profiles of ginsenosides after compatibility of P ginseng and V. nigrum L.

同期刊论文项目