中文摘要：

观察使用不同5-HT3受体拮抗剂预防全麻下腹腔镜手术术后恶心呕吐的临床效果。选择160例气管内插管全身麻醉下腹腔镜手术，随机分四组，每组40例，手术结束前30min分别静脉注射昂丹司琼4mg（A组）；托烷司琼2mg（B组）；格拉司琼3mg（C组）；D组为对照组。记录术后2h、6h、12h、24h患者恶心、呕吐出现的例数。结果四组患者术后恶心呕吐的发生率是一个逐渐下降的趋势，A、B、C三组与D组相比较有显著性差异（P〈0．05）；术后2h、6h、12hB组与A组、C组相比较有显著性差异（P〈0．05）；而术后24hA、B、C三组差异无统计学意义，A、B、C三组抑制恶心呕吐的有效率分别为67．5％、87．5％和70．0％，与对照组比较差异有统计学意义（P〈0．05），随访患者24h内无与药物相关的不良反应。结论：三种药物都能有效地预防术后恶心呕吐，但12h内托烷司琼的有效性更为明显。

英文摘要：

Observation of different 5-HT3 receptor antagonists in clinical effect of prevention of nausea and vomiting after laparoseopie operation under general anesthesia. The author chose 160 cases of endotracheal intubation under general anesthesia in laparoscopic operation, who were randomly divided into four groups, 40 cases in each group, respectively, before the end of operation 30min intravenous ondansetron 4mg （group A） ; tropisetron 2mg （group B） ; granisetron 3mg （C group） ; group D was the control group. The number of cases with nausea, vomiting were recorded after 2h, 6h, 12h, 24h. The patients of four groups after the incidence of nausea and vomiting is a trend of gradual decline, observation of A, B, C three group compared with the D group were significantly different （P〈0.05） ; after 2h, 6h, 12h, A, B group and C group compared with significant difference （P〈0.05） ; and after 24h A, B, C three groups no significant difference, A, B, C three groups inhibit nausea and vomiting effective rate were 67. 5%, 87. 5% and 70. 0%, there is a statistically significant difference compared with the control group （P〈0. 05）, no adverse reaction and drug related follow-up of patients 24h. Three drugs are effective in preventing postoperative nausea and vomiting, but the effectiveness of 12h Nero tropisetron was more obvious.