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银杏达莫对急性脑梗死患者血清补体C3、IL-6和IL-8的影响
  • ISSN号:1672-4208
  • 期刊名称:《社区医学杂志》
  • 时间:0
  • 分类:R743.3[医药卫生—神经病学与精神病学;医药卫生—临床医学]
  • 作者机构:[1]深圳市宝安区西乡人民医院,广东518102
  • 相关基金:深圳市宝安区科技局立项课题,编号:2012085
中文摘要:

目的探讨银杏达莫对急性脑梗死(ACI)患者血清补体C3、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平变化的影响。方法将ACI患者136例随机分为常规治疗对照组68例和银杏达莫治疗+常规治疗治疗组68例,分别治疗前及治疗4周后测定血清补体C3、IL-6及IL-8。同期另选40例健康体检者作参考组。结果ACI患者治疗前血清补体C3、IL-6及IL-8水平均明显高于参考组(P〈0.05)。治疗组经过治疗后血清补体C3、IL-6及IL-8水平均明显低于治疗前,并且更低于对照组,差异具有统计学意义(P〈0.05);与参考组比较无显著性差异(P〉0.05)。对照组患者治疗前后血清补体C3、IL-6及IL-8无显著性差异(P〉0.05)。结论 ACI患者应用银杏达莫治疗使补体C3、IL-6及IL-8显著降低,具有明显抗炎作用效果。

英文摘要:

Objective To explore the effects of ginkgo - dipyidamolum injection on serum complement C3, IL - 6 and IL - 8 in acute cerebral infarction(ACI). Methods 136 cases of ACI were randomly divided into two groups: control group and routine treatment plus ginkgodipyidamolum treatment group. Both groups were detected for serum complement C3, IL - 6 and IL - 8before treatment and 4 weeks after treatment. Meanwhile, 40 healthy subjects were as the reference group. Results Before treatment, serum levels of complement C3, IL - 6 and IL - 8 were significantly higher in patients with ACI than in reference group ( P 〈 0.05 ), but after treatment, the levels of the treatment group were obviously lower than before and even more, lower than the controls, the difference was statistically significant( P 〈0.05 ) ; no significant - difference was found when compared to those of reference group ( P 〉 0.05 ). Control groups showed no significant difference before and after treatment in the levels of serum complement C3, IL - 6 and IL - 8Conclusions Ginkgo - dipyi- damolum injection for ACT can lower the levels of the serum C3, IL - 6 and IL - 8, showing potent anti -inflammatory efficacy.

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期刊信息
  • 《社区医学杂志》
  • 主管单位:中华人民共和国国家卫生和计划生育委员会
  • 主办单位:中华预防医学会 山东省农村卫生协会
  • 主编:庞传武
  • 地址:山东省济南市浆水泉路11号
  • 邮编:250014
  • 邮箱:pcwpcw@163.com
  • 电话:0531-88934668
  • 国际标准刊号:ISSN:1672-4208
  • 国内统一刊号:ISSN:10-1026/R
  • 邮发代号:24-211
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:17464