目的探讨银杏达莫对急性脑梗死(ACI)患者血清补体C3、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平变化的影响。方法将ACI患者136例随机分为常规治疗对照组68例和银杏达莫治疗+常规治疗治疗组68例,分别治疗前及治疗4周后测定血清补体C3、IL-6及IL-8。同期另选40例健康体检者作参考组。结果ACI患者治疗前血清补体C3、IL-6及IL-8水平均明显高于参考组(P〈0.05)。治疗组经过治疗后血清补体C3、IL-6及IL-8水平均明显低于治疗前,并且更低于对照组,差异具有统计学意义(P〈0.05);与参考组比较无显著性差异(P〉0.05)。对照组患者治疗前后血清补体C3、IL-6及IL-8无显著性差异(P〉0.05)。结论 ACI患者应用银杏达莫治疗使补体C3、IL-6及IL-8显著降低,具有明显抗炎作用效果。
Objective To explore the effects of ginkgo - dipyidamolum injection on serum complement C3, IL - 6 and IL - 8 in acute cerebral infarction(ACI). Methods 136 cases of ACI were randomly divided into two groups: control group and routine treatment plus ginkgodipyidamolum treatment group. Both groups were detected for serum complement C3, IL - 6 and IL - 8before treatment and 4 weeks after treatment. Meanwhile, 40 healthy subjects were as the reference group. Results Before treatment, serum levels of complement C3, IL - 6 and IL - 8 were significantly higher in patients with ACI than in reference group ( P 〈 0.05 ), but after treatment, the levels of the treatment group were obviously lower than before and even more, lower than the controls, the difference was statistically significant( P 〈0.05 ) ; no significant - difference was found when compared to those of reference group ( P 〉 0.05 ). Control groups showed no significant difference before and after treatment in the levels of serum complement C3, IL - 6 and IL - 8Conclusions Ginkgo - dipyi- damolum injection for ACT can lower the levels of the serum C3, IL - 6 and IL - 8, showing potent anti -inflammatory efficacy.