中文摘要：

目的探讨E-钙粘附素基因（CDH1）启动子区-160C→A多态性与胃癌遗传易感性的关系。方法应用以人群为基础的病例对照研究，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测胃癌病例组与健康对照组的-160C→A多态改变的频率。结果CDH1-160C→A多态改变在胃癌病例组中的频率分别是CC型为57．8％、CA型为36．4％、AA型为5．8％，对照组各型频率分别是CC型为58．2％、CA型为34．9％、AA型为6．9％。调整年龄、性别、地区、吸烟、饮酒、饮茶、H．pylori感染以及胃癌家族史等因素后，CDH1各基因型在2组间差异均无统计学意义（χ^2=0．29，P=0．87）；将CA基因型与AA基因型合并后进行病例组与对照组之间的比较，差异无统计学意义（χ^2=0．01，P=0．92）。结论E-钙粘附素基因（CDHI）启动子区-160C→A多态性与胃癌遗传易感性不相关。

英文摘要：

Objective To test the hypothesis that a C to A variant in promoter of E-cadherin gene, which is associated with risk of developing non-cardia gastric cancer. Methods Population based case-control study was used and the poiymerase chain reaction-restriction fragment length polymorphisms（PCR-RFLP） was used to genotype this variant in 207 non-cardia gastric cancer patients and 270 age-sex frepuency-matched cancer free controls. Results The distributions of CDH1 genotypes were not significantly different between cases and controls（χ^2 = 0,29, P = 0.87）, Compared with the CC genotype, the variant CA and AA genotypes were not associated with an increased risk of gastric cancer [ adjusted odds ratio（ORa） were 1.15,0,90 respectively;95% confidence interval（CI） were 0.87- 1.72,0.42 - 2.01 respectively]. Conclusion The C→160a promoter polymorphism of E-cadherin gene may not play a major role in the etiology of non-cardia gastric cancer.