中文摘要：

目的：系统分析髓鞘碱性蛋白（MBP）在不同程度缺血缺氧性脑病（HIE）新生儿血清水平变化。方法：计算机检索中国知网、万方数据、PubMed、Embase、Web of Science和Cochrane Library等数据库,从建库至2016-11-25收录的有关HIE新生儿MBP血清水平变化的研究。对符合纳入和排除标准的随机或半随机对照研究进行数据提取和质量评估后,用RevMan5.3软件对文献数据进行Meta分析。结果：共检索文献156篇,最终纳入6篇。6篇文献结果数据均完整,对结局指标均有报道,不存在选择性结果报道,其它潜在偏倚风险不确定。Meta分析显示,与对照组相比,轻度、中度和重度HIE均可引起新生儿外周血MBP水平升高,且重度〉中度〉轻度。轻度HIE新生儿MBP水平合并标准化均数差（SMD）=1.82（95%CI：0.65-2.99,P〈0.01）,中度HIE新生儿MBP水平SMD=4.02（95%CI：1.55-6.49,P〈0.01）,重度HIE新生儿MBP水平SMD=6.06（95%CI：3.35-8.78,P〈0.01）。中度与轻度HIE相比,MBP水平SMD=2.46（95%CI：0.71-4.22,P〈0.01）;重度与轻度HIE相比,MBP水平SMD=4.85（95%CI：2.59-7.10,P〈0.01）;重度与中度HIE相比,MBP水平SMD=2.94（95%CI：1.21-4.67,P〈0.01）。纳入6项研究存在明显发表偏倚。结论：不同程度HIE新生儿外周血MBP水平升高可为其临床诊断提供帮助。

英文摘要：

Objective：To systematic analysis the changes of serum myelin basic protein（MBP）levels in hypoxic-ischemic encephalopathy（HIE）.Method：Obtained the documents about the myelin basic protein level in serum in hypoxic-ischemic encephalopathy by searching the Cochrane library,PubMed,EMBASE,Web of Science,CNKI and WanFang Database（from building a datebase to November 2016）.Data extraction and quality evaluation were performed after a randomized or semi randomized controlled study that met inclusion and exclusion criteria.Then the meta-analysis was performed by review manager version 5.3.Results：A total of 6documents were involved.Meta analysis showed：compared with the control groups,varying degrees of HIE increaed the level of MBP in serum.The difference between two groups was statistically significant,the combined volume of MBP level in mild HIE SMD=1.82（95%CI：0.65-2.99）,MBP combined in moderate HIE SMD=4.02（95%CI：1.55-6.49,P〈0.01）,MBP combined in severe HIE SMD = 6.06（95%CI：3.35-8.78,P〈0.01）.Compared with the mild HIE,MBP combined in moderate HIE SMD=2.46（95%CI：0.71-4.22,P〈0.01）,MBP combined in severe HIE SMD=4.85（95%CI：2.59-7.10,P〈0.01）,compared with the moderate HIE,MBP combined in severe HIE SMD=2.94（95%CI：1.21-4.67,P〈0.01）.Conclusion：Different levels of HIE neonatal peripheral blood MBP levels may help to provide clinical diagnosis.