中文摘要：

目的：了解伽马刀治疗多发脑转移瘤预后的影响因素,从而提高多发脑转移瘤患者的生存率。方法：选择使用伽马刀治疗的多发脑转移瘤患者238例并回顾性分析各种因素对于患者生存率的影响。结果：多发脑转移瘤的中位生存时间为206天,单因素分析伽马刀治疗多发脑转移瘤与KPS、放射剂量、中枢外转移以及原发病灶控制等4个单因素有关;多因素回归分析最后得出,KPS（P=0.003,Wald=9.100）、中枢外转移（P=0.019,Wald=6.542）以及原发病灶控制（P=0.002,Wald=11.492）是影响伽马刀治疗多发脑转移瘤预后的因素。结论：影响多发脑转移瘤患者预后的主要因素包括KPS、中枢外转移以及原发病灶控制。

英文摘要：

Objective：To investigate the influencing factors of gamma knife in the treatment of multiple brain me-tastasis for prognosis,so as to improve the survival rate of patients with multiple brain metastatic tumor. Methods：238 cases of patients were retrospectively analysed with various factors in the survival rate of patients with metastasis using gamma knife treatment of multiple brain. Results： The median survival time of multiple brain metastases was 206 days. The single factor analysis showed multiple brain metastases were related with KPS, radiation dose, metastasis outside the central nervous system and the primary lesions control. Multifactor regression analysis concluded that the KPS（P =0.003 ,Wald =9. 100） ,metastasis outside the central nervous system（P =0.019, Wald = 6.542） and pri-mary lesions control（P = 0.002, Wald =11.492） were prognostic factors in gamma knife treatment of multiple brain metastasis tumor. Conclusion： The main factors that affect the prognosis of patients with multiple brain metastases should include KPS, metastasis outside central nervous system and primary lesion control.