中文摘要：

建立了一个三维光热模型,应用该模型分别研究了红外激光脉冲在人耳蜗和动物耳蜗内由于激光吸收引起的温度变化。采用有限元方法,数值模拟了耳蜗内温度在空间和时域的变化。研究发现尽管激光吸收引起了一定的温度升高,但是可以通过调节激光脉冲参数比如激光功率和重复频率对温度变化进行控制。通过对比相同参数的激光脉冲在豚鼠耳蜗内和人耳蜗内引起的温度变化,发现动物耳蜗内温度升高较明显。因此从激光热效应的角度看,动物实验能有效帮助合理选择激光在人耳蜗内的安全参数。

英文摘要：

A simplified 3D model has been developed to simulate heating effects in human cochlea and guinea pig cochlea when infrared laser pulses are applied to stimulate their ganglion neurons. It simplifies the spiral structure of the cochlea by a rota- tional symmetry with the 3D structure of the cochlea, and applies the finite element method to solve the heat equation and allows de- tailed investigation of the temperature rise in spatial and temporal domains. The numerical results show that the temperature rises within cochleae can he controlled in a safe range by adjusting the laser power and repetition rate. Additionally, the results show that the heating in guinea pig cochlea is higher than that in human eoeldea because of the effect of the boundary conditions. It indicates that experiments with laser safety performed on guinea pig cochlea could be a good guidance for studying laser safety in human.