中文摘要：

目的：探讨PGP9．5和CyclinDl在皮肤鳞状细胞癌（CSCC）、Bowen病中的表达及临床意义。方法：用免疫组织化学sP法检测22例CSCC，31例Bowen病及10例正常皮肤组织中PGP9．5和CyclinDl的表达情况。结果：PGP9．5与CyclinDl在CSCC的表达明显高于正常皮肤组（P=O．006，P=0．00057，〈0．05）和Bowen病组（P〈0．05），PGP9．5与CyclinDl在低分化鳞癌的表达明显强于高分化鳞癌的表达（P〈O．05）。在CSCC、Bowen病中，PGP9．5与CyclinDl的阳性表达存在相关性。结论：PGP9．5、CyclinDl的高表达和鳞癌细胞分化程度有密切关系。

英文摘要：

Objective To study the expression of PGP9.5and CyclinD1 in Cutaneous squamous cell carcinoma and Bowen＇s disease and exploring the relationship between them and to confirm their role in development of the tumor. Methods Immunohistochemical S-P method was used to examine the expressions of PGP9.5 and CyclinD1 in 22 cases of CSCC, 31cases of Bowen＇s disease, and 10 cases of normal skin. Results The expression of PGP9.5 and CyclinD1 was significantly higher in CSCC than in normal tissue and Bowen＇s disease （P=0.006,P=0.00057 〈0.05）. The expression of PGP9.5 and CyclinD1 was significantly stronger in poorly differentiated CSCC than in well differentiated CSCC （P〈0.05）, The positive expression of PGP9.5 and CyclinD1 are positive correlations in CSCC and Bowen＇s disease. Conclusion The co-expression of PGP9.5 and CyclinD1 is related with carcinogenesis and malignant progression of CSCC and Bowen＇s disease.