中文摘要：

学习是决定 SUMO4 M55V 多型性是否与危险性被联系打 2 糖尿病 mellitus ( T2DM ) .MethodsA 元分析的这的 ObjectiveThe 目的被执行检测 SUMO4 M55V 多型性和危险性的潜在的协会到 T2DM 在下面主导，后退，co主导(同类、异构)，并且包括 10 盒子控制的八篇文章的添加剂 models.ResultsA 总数学习与 2932 个盒子和 2679 控制的一个总数，在这被包括在到 T2DM 的 SUMO4 M55V 多型性和危险性之间的重要协会在主导的模型被观察(GG + GA 对 AA：或 = 1.21， 95% CI = 1.05-1.40， P = 0.009 ) ，后退的模型(GG 对 GA + AA：或 = 1.29， 95% CI = 1.07-1.356， P = 0.010 ) ，同型结合的模型(GG 对 AA：或 = 1.41， 95% CI = 1.06-1.56， P = 0.001 ) ，并且添加剂模型(G 对 A：或 = 1.18， 95% CI = 1.08-1.29， P = 0.001 ) ，并且在异质接合的模型稍微重要(GA 对 AA：或 = 1.16， 95% CI = 0.98-1.36， P = 0.080 ) 。在亚群分析，重要协会在排除异质接合的模型的四个基因模型下面在中国人口被观察，而没有统计上重要的协会在每五基因 models.ConclusionThe 下面在日本人口被观察，元分析证明 SUMO4 M55V 多型性的 G 等位基因能是到 T2DM 的一个易受影响的风险地点，主要在中国人口，当在另外的种族人口的协会需要是 furthe 时

英文摘要：

Objective The aim of this study is to determine whether the SUMO4 M55V polymorphism is associated with susceptibility to type 2 diabetes mellitus （T2DM）. Methods A meta-analysis was performed to detect the potential association of the SUMO4 M55V polymorphism and susceptibility to T2DM under dominant, recessive, co-dominant （homogeneous and heterogeneous）, and additive models. Results A total of eight articles including 10 case-control studies, with a total of 2932 cases and 2679 controls, were included in this meta-analysis. The significant association between the SUMO4 M55V polymorphism and susceptibility to T2DM was observed in the dominant model （GG ＋ GA versus AA： OR = 1.21, 95% CI = 1.05-1.40, P = 0.009）, recessive model （GG versus GA ＋ AA： OR = 1.29, 95% CI = 1.07-1.356, P = 0.010）, homozygous model （GG versus AA： OR = 1.41, 95% CI = 1.06-1.56, P = 0.001）, and additive model （G versus A： OR = 1.18, 95% CI = 1.08-1.29, P = 0.001）, and marginally significant in the heterozygous model （GA versus AA： OR = 1.16, 95% CI = 0.98-1.36, P = 0.080）. In subgroup analyses, significant associations were observed in the Chinese population under four genetic models excluding the heterozygous model, whereas no statistically significant associations were observed in the Japanese population under each of the five genetic models. Conclusion The meta-analysis demonstrated that the G allele of the SUMO4 M55V polymorphism could be a susceptible risk locus to T2DM, mainly in the Chinese population, while the association in other ethnic population needs to be further validated in studies with relatively large samples.