中文摘要：

目的 探讨不同时间给予去铁胺对大鼠实验性颅脑创伤的治疗作用。方法 选取健康成年雄性SD大鼠39只,体质量210-310 g,随机分为致伤组、早期治疗组和延期治疗组,每组13只。制备颅脑创伤模型,早期治疗组模型制备2 h即给予去铁胺100 mg/kg（1 m L生理盐水稀释）,延期治疗组在模型制备3 d后给予等量去铁胺,而致伤组仅给予等量生理盐水,均治疗至28 d。分别于伤后56 d处死前完成Morris水迷宫实验,处死动物后完成病理学检查,包括大体标本、苏木精-伊红（HE）和尼氏染色。结果 （1）Morris水迷宫实验：早期治疗组大鼠平台搜索策略和搜索时间[分别为（3.25±0.16）分、（36.58±9.27）s]与致伤组[分别为（2.13±0.30）分、（110.00±16.74）s]比较,差异均有统计学意义（P〈0.05）;而延期治疗组大鼠平台搜索策略和搜索时间[分别为（2.50±0.27）分、（96.08±10.66）s]与致伤组比较,差异均无统计学意义（P〉0.05）。（2）大体标本：去铁胺早期治疗组大鼠大脑缺损体积[（126.68±15.23）mm3]较致伤组[（212.36±18.43）mm3]明显缩小,差异有统计学意义（P〈0.05）;延期治疗组[（178.71±30.36）mm3]与致伤组大鼠大脑缺损体积与比较,差异无统计学意义（P〉0.05）。（3）HE及尼氏染色：早期治疗组伤区残腔周围残留片状细胞皱缩带较窄,皱缩带可见较多皱缩神经元分布;延期治疗组该皱缩带较早期治疗组有所增宽;致伤组该皱缩带最明显,且残留神经元鲜见。结论 大鼠大脑打击伤后早期（2 h）给予去铁胺,能显著改善其空间学习记忆能力、缩小大脑缺损体积及减少致伤灶周围神经元死亡,从而起到神经保护作用,而延期治疗（3 d）则无效。

英文摘要：

Objective To explore the effects of giving deferoxamine at different time on experimental traumatic brain in-jury（TBI） in rats. Methods 39 healthy male adult Sprague-Dawley rats,weighted 210~310 g,were selected and divided into the injury group,early treatment group and delayed treatment group,13 cases in each group. The TBI model was prepared. The early treatment group was given deferoxamine100 mg/kg（dilution by 1m L of normal saline） at 2 h after TBI model preparation,the delayed treatment group was given the same volume of deferoxamine on 3 d after model preparation,while the injury group was given the same volume of normal saline, the treatment lasted for 28 d. Before the rats were killed on 56 d, the Morris water maze test was completed,and then the pathological examination was performed after killing rats,including the gross samples,HE staining and Nissl staining. Results（1）The Morris water maze test：the time of platform search strategy and search time in the early treatment group were（3.25±0.16）scores and（36.58±9.27）s,respectively,which in the injury group were（2.13±0.30）scores and（110±16.74）s,respectively. The difference was statistically significant（P〈0.05）,while which in the delayed treatment group were（2.50±0.27）scores and（96.08±10.66）s,respectively,showing no statistical difference compared with the injury group（P〉0.05）;（2）the gross samples：the brain defect volume in the early treatment group was（126.68±15.23）mm3,which was significantly decreased compared with the injury group（212.36±18.43）mm3,the difference was statistically significant（P〈0.05）,the brain defect volume（178.71±30.36）mm3 in the delayed treatment group showed no statistical difference compared with the injury group（P〉0.05）;（3）the HE and Nissl staining：flaky cellular shrinkage band around residual cavity in the injury area in the early treatment group was relatively narrow,more shrinkage neurons distribution could be found in the shrinkage band;