中文摘要：

目的探讨高血压前期人群一氧化氮水平的性别差异,并分析其与循环内皮祖细胞（EPC）数量和功能的相关性。方法招募80例平均年龄为46.4±4.3岁的人群作为研究对象,其中21例绝经前健康女性,20例绝经前高血压前期女性,19例健康男性和20例高血压前期男性,测定四组血浆和EPC分泌的一氧化氮、粒-巨噬细胞集落刺激因子和血管内皮生长因子水平。结果与健康男性组和高血压前期男性组比较,绝经前健康女性组和绝经前高血压前期女性组血浆和循环EPC分泌的一氧化氮水平明显增加（P〈0.05）;健康男性组血浆和循环EPC分泌的一氧化氮水平比高血压前期男性组高（P〈0.05）;而绝经前健康女性组和绝经前高血压前期女性组血浆和循环EPC分泌的一氧化氮水平无明显差异（P〉0.05）;血浆一氧化氮水平或循环EPC分泌的一氧化氮水平与循环EPC数量及功能呈明显的直线相关关系（P〈0.05）。四组血浆和EPC分泌的血管内皮生长因子和粒-巨噬细胞集落刺激因子水平无明显差异（P〉0.05）。结论相对高血压前期男性患者,绝经前高血压前期女性人群一氧化氮水平受到保护,且一氧化氮水平与EPC数量和功能相关。

英文摘要：

Aim To investigate the gender differences in the levels of nitric oxide in prehypertension and its correlation with the number and function of circulating endothelial progenitor cells. Methods Eighty consecutive population,46. 4 ± 4. 3 years old,were divided into four groups： normotensive premenopausal women（ n = 21）,prehypertensive premenopausal women（ n = 20）,normotensive men（ n = 19） and prehypertensive men（ n = 20）. The nitric oxide（ NO）,granulocyte-macrophage colony stimulating factor（ GM-CSF） and vascular endothelial growth factor（ VEGF） levels in plasma and secreted by circulating EPCs were measured in the four groups. Results The distribution of plasma NO level,the NO secretion by cultured EPCs in normotensive and prehypertensive premenopausal women were significantly higher than those in normotensive and prehypertensive men（ P 0. 05）. The plasma NO level or NO secretion by EPC in normotensive men was also higher than that in prehypertensive men（ P 0. 05）. However,the plasma NO level or NO secretion by EPC in normotensive premenopausal women was almost equal to that of prehypertensive premenopausal women（ P〉0. 05）. The plasma NO level or NO secretion by EPC was related to the number or activity of circulating EPC. No significant difference was found in plasma VEGF or GM-CSF level in the four groups（ P〉0. 05）. Conclusions The plasma NO level and NO secretion of circulating EPC were preserved in prehypertensive premenopausal women,which was correlated with the number and activity of circulating EPC.