中文摘要：

近年来，许多研究证实，表观遗传学及乙酰化调控在慢性肝炎、原发性肝癌的发病机制中都发挥了重要作用。本文较系统地介绍了乙酰化调控及相关信号通路在肝衰竭发生过程中的作用及可能机制，为肝衰竭提供了新的潜在干预治疗思路。

英文摘要：

In recent years, many studies have confirmed that epigenetics and acetylated regulation play the important roles in the pathogenesis of chronic hepatitis and primary hepatocellular carcinoma. This paper systematically introduced the roles and possible mechanisms of the acetylation and its related sigual pathway in the pathogenesis of liver failure, which could provided a potential novel strategy for the therapy of liver failure.