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中文摘要：
严重烧、创伤及外科大手术应激打击极易诱发脓毒症等感染并发症，进一步发展可导致脓毒性休克、多器官功能障碍综合征（Multiple organ dysfunction syndrome，MODS），是临床烧、创伤和危重患者最主要死亡原因之一。创伤脓毒症发病机制非常复杂、临床救治十分困难，内容涉及感染、炎症、免疫、凝血及组织损害等一系列基本问题，并与机体多系统、多器官病理生理改变密切相关。因此，深入探讨创伤脓毒症的发生规律与病理生理机制，寻求新的有效防治途径，对于创伤脓毒症的早期识别、诊断和干预，降低患者的病死率及提高生活质量具有重要意义。
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