骨形态发生蛋白(BMPs)是转化生长因子-β(TGF-D)超家族的成员,具有多种生理功能,如胚胎形成、骨代谢、造血作用以及神经形成等。近年来研究发现,BMPs还与糖、脂类及能量代谢密切相关,并参与糖尿病及其并发症如糖尿病性肾病、糖尿病视网膜病变、糖尿病血管病变等过程的调节。同时BMPs可以从代谢角度调节糖尿病型肥胖的发生,为未来糖尿病的治疗提供了新的思路。
Bone morphogenetic proteins (BMPs) belong to the superfamily of transforrning growth factor-13 (TGF-I3), and are involved in multi-physiological functions, such as embryogenesis, bone metabolism, hemopoiesis, and neurogenesis. Recent studies suggest that BMPs be also closely associated with the metabolism of glucose, lipid and energy, and take part in the regulation of diabetes and its complications, including diabetic nephropathy, diabetic retinopatby, diabetic vascular lesions, and other processes. Therefore, BMPs can be used to regulate the development of diabetic obesity, and provide a new thought for the future treatment of diabetes.