蛋白质褶层结构是比它的氨基酸顺序保存并且仔细与生物功能联系了推测蛋白质结构的类似是在结构的生物学的一个基本问题并且在蛋白质褶层分类,褶层功能推理,和蛋白质结构起一个关键作用的更多预言。大进步为认为结构的类似被建议了在这块地和许多方法里在最近的年里被取得了,包括为蛋白质结构比较,从数据库的蛋白质结构的检索,和 ligand 绑定的方法地点比较。大多数那些方法能在万维网上是可得到的,但是所有方法的评估仍然是一个难问题。这篇论文为结构类似总结一些流行方法和最近的方法,包括结构排列,蛋白质结构检索,和 ligand 绑定地点排列。
Protein fold structure is more conserved than its amino acid sequence and closely associated with biological function, so calculating the similarity of protein structures is a fundamental problem in structural biology and plays a key role in protein fold classification, fold function inference, and protein structure prediction. Large progress has been made in recent years in this field and many methods for considering structural similarity have been proposed, including methods for protein structure comparison, retrieval of protein structures from databases, and ligand binding site comparison. Most of those methods can be available on the World Wide Web, but evaluation of all the methods is still a hard problem. This paper summarizes some popular methods and latest methods for structure similarities, including structure alignment, protein structure retrieval, and ligand binding site alignment.