中文摘要：

以红霉素为模板分子,采用溶胶-凝胶印迹技术,合成对红霉素具有特异选择识别性能的印迹聚合材料.采用红外光谱、扫描电子显微镜、热重分析以及比表面积测定技术对印迹聚合物的结构和表面性能进行详细探讨,结果表明所得印迹聚合物比表面积为266.2m^2/g,粒径为600nm左右的颗粒材料.选择3种抗生素类药物进行选择吸附研究,结果表明,该聚合物对红霉素的分离因子最高达到2.20.优化固相萃取条件,结果表明用甲醇：乙酸（75：25,V/V）作为洗脱剂时对红霉素的洗脱效果最好.结合液相色谱技术,该印迹材料成功的分离和富集红霉素肠溶片中的红霉素,回收率达到104.5%。

英文摘要：

A highly selective molecularly imprinted polymer（MIP） was prepared by a simple molecular imprinting technique with a sol-gel process.Erythromycin was used as template,3aminopropyltrimethoxysilane（APTMS） as functional monomer and tetraethylorthosilicate（TEOS） as reticulating agent.Infrared spectroscopy,scanning electron microscopy,thermogravimetric and surface area analyses were used to characterize the composite structure and morphology in detail.The results showed that the specific surface area of MIP was 266.2 m^2 /g.These imprinted polymer particles had perfect spherical shape with average size of 600 nm and exhibited especially selective recognition for erythromycin.Equilibrium binding experiment showed that the separation factor was 2.20 when erythromycin was separated by using MIP.The elution condition was optimized,and the optimal condition was methane：acetic acid（75：25,V /V） as eluent,and the optimal elution volume was 15 mL.The recovery of erythromycin was 103.1% by using 15 mL mixture of methane：acetic acid（75：25,V /V） as eluent.Packed in solid phase extraction column,the polymer was used to extract erythromycin from erythromycin enteric-coated tablets.The results indicated that the polymer can separation and enrich erythromycin from erythromycin enteric-coated tablets successfully with the recovery of 104.5%.