中文摘要：

目的评价血清半乳甘露聚糖(GM)试验在诊断马尔尼菲青霉感染(PSM)中的应用价值。方法收集2012~2015年间确诊PSM患者37例、其他真菌感染患者17例、健康志愿者30例血清,进行GM试验检测;同时评价其中4例PSM患者治疗前后GM值变化,计算诊断指标并分析评价。结果 GM试验对PSM患者总体敏感度为78.38%,特异度为82.98%;其中对HIV阳性PSM患者敏感度为76.47%,特异度为97.87%;对HIV阴性PSM患者敏感度为75.00%,特异度为84.78%。4例随访的PSM患者经抗真菌药物治疗后,随着病情好转,GM水平逐渐下降。结论 GM试验对PSM有一定的诊断价值,尤其对马尔尼菲青霉流行地区的HIV感染者,早期诊断PSM有重要意义。

英文摘要：

Objective To evaluate the value of the galactomannan antigen assay in diagnosis Penicilliosis marneffei (PSM).Methods The serum samples were collected from 37 PSM patients,17 other fungal infection patients and 30 healthy volunteers.Platelia Asper-gillus enzyme immunoassay kit was used.Results The sensitivities of total PSM patients,PSM patients with or without HIV infec-tion were 78.38%,76.47%,75.00%,while their specificities were 82.98%,97.87%,84.78%,respectively.In 4 follow-up PSM pa-tients,the GM decreased after anti-fungi treatment for 1 week as the clinical presentation improved.Conclusion This study showed that the GM test was significantly elevated for HIV patients with penicilliosis.The use of the GM antigen assay may facilitate earlier diag-nosis of Penicillium marneffei infection for HIV-infected patients in areas of endemicity.