中文摘要：

设计 E 的一个全面新陈代谢网络。coli 在系统生物学是很重要的， metabolomics 学习。许多工具集中于二维的空格在新陈代谢的网络显示小径。然而，三维的可视化的用法可以帮助更好理解新陈代谢、规章的网络的复杂拓扑学。方法我们手工地从文学的大量试验性的数据(包括的小径，反应和代谢物) 与设计 E 的不同类型联系了的 curated。coli 然后利用了三维的可视化的一种新奇技术开发一个全面新陈代谢的网络命名 SynBioEcoli。结果 SynBioEoli 包含 740 条 biosynthetic 小径， 3,889 新陈代谢的反应， 2,255 化学药品手工地从与设计 E 的不同类型联系的大约 11,000 份新陈代谢出版物加重 curated。coli。而且， SynBioEcoli 与各种各样的信息科学技术集成。结论 SynBioEcoli 能被认为是设计 E 的全面 knowledgebase。coli 并且代表下一代细胞的新陈代谢网络可视化技术。它能经由浏览器被存取(例如 Google 铬) 支持 WebGL，在 http://www.rxnfinder.org/synbioecoli/ 。

英文摘要：

Background： A comprehensive metabolism network of engineered E. coli is very important in systems biology and metabolomics studies. Many tools focus on two-dimensional space to display pathways in metabolic network. However, the usage of three-dimensional visualization may help to understand better the intricate topology of metabolic and regulatory networks. Methods： We manually curated large amount of experimental data （including pathways, reactions and metabolites） from literature related with different types of engineered E. coli and then utilized a novel technology of three dimensional visualization to develop a comprehensive metabolic network named SynBioEcoll. Results： SynBioEoli contains 740 biosynthetic pathways, 3,889 metabolic reactions, 2,255 chemical compounds manually curated from about 11,000 metabolism publications related with different types of engineered E. coil Furthermore, SynBioEcoli integrates with various informatics techniques. Conclusions： SynBioEcoli could be regarded as a comprehensive knowledgebase of engineered E. coli and represents the next generation cellular metabolism network visualization technology. It could be accessed via web browsers （such as Google Chrome） supporting WebGL, at http：//www.rxnfinder.org/synbioecoli/.