An improved coupling reaction between aromatic ring and acetylene triple bond catalyzed by palladium (0) catalyses for the preparation of pyridylethynyl benzoni-trile compounds is described. Efforts were made to improve the reaction by changing different reaction conditions and it was found that the solvent is one important factor in this situation.
An improved coupling reaction between aromatic ring and acetylene triple bond catalyzed by palladium (0) catalyses for the preparation of pyridylethynyl benzonitrile compounds is described. Efforts were made to improve the reaction by changing different reaction conditions and it was found that the solvent is one important factor in this situation.